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[38] found that in both PASMC and PAH rats, HIF-1 regulated mitochondrial dynamics during hypoxia-induced pulmonary vasculature remodeling by directly lowering Drp1 expression and increasing the expression of Mfn2 (Figure 1)

Interestingly, enhanced endogenous sulfur dioxide (SO 2 ) level in endothelial cells and increased enzymatic activity of aspartate aminotransferase (AAT), a major SO 2 synthesis enzyme, were observed in a rat model of MCH-induced PH (Zhang D

S., Peeters, M., Kingma, I., & Smit, T

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